Trans -Forming Endothelial Nitric Oxide Synthase in Hypertension
نویسندگان
چکیده
منابع مشابه
Trans-forming endothelial nitric oxide synthase in hypertension: more than meets the eye.
Endothelium exerts diverse effects within the vessel wall and on nearby target cells.1 Through these effects, endothelial cells inhibit vascular tone and vascular growth and protect against thrombosis and progression of atherosclerosis, as well as increases in blood pressure.1,2 Much of the influence of endothelium on other cells is mediated by intercellular signals carried by diffusible factor...
متن کاملthe analysis of endothelial nitric oxide synthase gene polymorphism in intron 4 with hypertension disease
nitric oxide is an important vasorelaxant factor that it inhibits platelet adhesion and proliferation of smooth muscle cells. no is synthesized from l-arginine by means of endothelial nitric oxide synthase (enos) which is an isoform of nitric oxide synthase.in the present study, we examined possible association between the 27 base pair (bp) repeat polymorphism in intron 4 of the enos3 gene ...
متن کاملEXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE GENE (iNOS) STIMULATED BY HYDROGEN PEROXIDE IN HUMAN ENDOTHELIAL CELLS
Inducible nitric oxide synthase (iNOS) gene expresses a calcium calmudolin-independent enzyme which can catalyse NO production from L-arginine. The induction of iNOS activity has been demonstrated in a wide variety of cell types under stimulation with cytokines and lipopoly saccharide (LPS). Previous studies indicated that all nitric oxide synthases (NOS) activated in human umbilical vein endot...
متن کاملNitric oxide produced by endothelial nitric oxide synthase promotes diuresis.
Extracellular fluid volume is highly regulated, at least in part, by peripheral resistance and renal function. Nitric oxide (NO) produced by NO synthase type 3 (NOS 3) in the nonrenal vasculature may promote fluid retention by reducing systemic vascular resistance and arterial pressure. In contrast, NO produced by renal NOS 3 promotes water excretion by reducing renal vascular resistance, incre...
متن کاملAssociation of endothelial nitric oxide synthase gene G894T polymorphism with type two diabetes and diabetic nephropathy
Background: Nitric oxide (NO) produced by endothelial NO synthase (eNOS) mediates a large range of processes, and abnormality in the production of NO has been implicated in diabetic complications including diabetic nephropathy (DN). G894T polymorphism in the eNOS gene has been shown to decreased activity the NO levels of plasma. The association between eNOS Glu298Asp gene polymorphism and DN ri...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2011
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.111.177139